Introduction: Why CRISPR Screening Still Feels Slow CRISPR-Cas9 technology has revolutionized gene editing, but biotech teams ...

Using CRISPR-Cas9, scientists can make precise changes to the genome during brain development, and then closely study how those changes affect individual cells using single-cell transcriptomic ...

MIC-Drop, which stands for Multiplexed Intermixed CRISPR Droplets, solves that problem by packaging the components of the CRISPR system into microscopic oil-encased droplets, which can mingle together ...

In the study, "Targeting the SHOC2–RAS interaction in RAS-mutant cancers," published in Nature, researchers conducted a genome-wide CRISPR screen to identify genetic dependencies associated with ...

A new CRISPR screen method developed at Scripps Research has the potential to improve studies into the genetic underpinnings of human diseases and disorders. The method was outlined in Cell, in a ...

This is a well-written study that presents a solid genetic screen to identify regulators of adipose morphology and remodeling in zebrafish. The authors generated a rigorous screening platform based on ...

Using a new CRISPR-based methodology for modulating DNA structure to enact epigenetic control over specific genes, a team of researchers has identified a “master regulator” gene capable of improving T ...

Cancer Consortium members Dr. Michael Emerman, Dr. Steven Henikoff, and Dr. Patrick Paddison contributed to this work. E Hsieh, DH Janssens, PJ Paddison, EP Browne, S Henikoff, M OhAinle, and M ...

Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma ...