Chinese companies are involved in one-fifth of pharma’s clinical development programs, but trade wars and regulatory hurdles ...

CRISPR-Cas systems have been exploited for targeted genome editing. CRISPR-Cas13 RNA-targeting systems comprise an invaluable set of tools in the fields of basic and applied sciences. Here ...

6 CRISPR’s capacity to cut and modify genes ... such as COVID-19 and human cytomegalovirus. 7,8 Cas12 and Cas13, relatives of Cas9, are particularly adept at this task. When these enzymes ...

Advancements in genome editing, particularly CRISPR, are reshaping precision biology, driving innovations in medicine, agriculture, and synthetic biology.

In particular, RNA-targeting CRISPR-Cas13 proteins are promising single-effector systems to regulate target mRNAs without altering genomic DNA, yet the current Cas13 systems are restrained by ...

CRISPR-Cas12 and CRISPR-Cas13 exhibit targeted recognition and cleavage of double-stranded DNA (dsDNA) and RNA, respectively (Pickar-Oliver and Gersbach, 2019). When selectively targeting homologous ...

The application of the type II CRISPR effector protein Cas9 as a sequence-specific nuclease in gene editing has revolutionized this field. Similarly, Cas13 as the effector protein of type VI provides ...