Researchers at Karolinska Institutet, led by Dr. Helin Norberg and Dr. Erik Norberg, have identified a previously unknown ...

This month's cover highlights the article Boosting human immunology: Harnessing the potential of immune organoids by Dirk Baumjohann and Maximilian Moll. The review article explores recent advances in ...

The study, published in EMBO Molecular Medicine, shows that a process called chaperone-mediated autophagy (CMA) may function as a natural defense mechanism against metastases. Cancer remains one of ...

Although macroautophagy is the most prominent form of autophagy, microautophagy and chaperone-mediated autophagy also perform key functions. Microautophagy directly engulfs cytoplasmic components into ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC). β-GC hydrolyzes glucosylceramide (GluCer) ...

BACKGROUND Rickettsia is a genus of Gram-negative bacteria that causes various diseases, including epidemic typhus, Rocky Mountain spotted fever, and Mediterranean spotted fever. Ticks transmit these ...