Aim: There remains high unmet medical need for therapies to treat cardio/metabolic diseases. We validated in human trials, a platform for reducing the synthesis of genes expressed in the liver. The ...

Figure 4. Complement. The complement system is activated by the classical, lectin, and alternative pathways. These pathways converge at C3, a pivotal protein with respect to both feedback and ...

Biontech SE and Bristol Myers Squibb Co. are teaming up to develop Biontech’s BNT-327 in a deal possibly worth over $11 billion. BNT-327 is in the hot new class of bispecific antibodies targeting ...

On May 29, 2025, C3.ai, Inc. (NYSE:AI) announced that the United States Air Force (USAF) Rapid Sustainment Office (RSO) has increased its contract ceiling to $450 million. The contract will run ...

In this article, we are going to take a look at where C3.ai Inc. (NYSE:AI) stands against other AI stocks on Wall Street’s radar. On May 29, Morgan Stanley analyst Sanjit Singh raised the price ...

Functionally, TSP-1 impeded factor D-mediated cleavage of factor B and the subsequent generation of the C3 convertase. In addition, TSP-1 blocked C5 cleavage and reduced C5a production in a cobra ...

Novel findings are shown regarding the interaction of propeptide phosphorylation and convertase cleavage, both of which will move the field forward. Lastly, a provocative hypothesis regarding furin ...

This fundamental work presents two clinically relevant BMP4 mutations that contribute to vertebrate development. The compelling evidence, both from wet lab and AI generated predictions, supports that ...

In this study, we report that host complement C3 significantly enhances malaria transmission by modulating the abundance of the antimalarial bacterium Elizabethkingia anophelis in the mosquito midgut.

Department of Proteomics and Signal Transduction, Max-Planck-Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany, Center for Experimental BioInformatics (CEBI), Department of ...

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