Escherichia coli, J&J and Sanofi

J&J, Sanofi stop E.coli vaccine trial due to low effectiveness
Johnson & Johnson and partner Sanofi will stop a late-stage trial of an experimental vaccine to prevent infections caused by the E.coli bacteria due to a lack of sufficient efficacy, the companies said on Thursday.
Johnson & Johnson halts late-stage E.coli vaccine trial after poor results
Johnson & Johnson and Sanofi said that while the vaccine showed no safety concerns, it did not meet the necessary effectiveness thresholds.
J&J stops Phase III trial of Sanofi’s E. Coli vaccine citing ‘disappointing’ results
The company said it will stop the Phase III trial of ExPEC after interim results found it failed to demonstrate efficacy over placebo.
Sanofi, J&J abandon trial of E coli vaccine after poor data
Johnson & Johnson and Sanofi's vaccine for preventing invasive disease caused by the problem pathogen Escherichia coli looks all but defunct after the two partners halted a phase 3 trial.
Sanofi and J&J discontinue late stage trial of their experimental E.coli vaccine
Due to the discontinuation, Sanofi said that it has recorded an impairment charge before tax of $250 million in the Q4 2024 IFRS results. It will further negatively impact the full-year IFRS EPS reported in the Q4 2024 results by €0.15 from €4.59 previously to €4.44 now, according to the company's statement.
Sanofi Ends E.coli Vaccine Trial Amid Efficacy Concerns
Sanofi ( ($SNY) ) has provided an announcement. On February 13, 2025, Sanofi announced the discontinuation of the E.mbrace phase 3 study for its
The Scientist11d
How Bacteria Outsmart Disinfectants
Disinfectants induce oxidative damage in bacteria, but a single mutation triggers the expression of genes that help the ...
Tackling the threat of drug-resistant E. coli in China
A comprehensive seven-year study across 20 Chinese provinces has revealed a concerning rise in antimicrobial resistance (AMR) ...
Hong Kong doctor dies, 2 others treated in suspected E coli cluster
Investigation under way into trio of oncologists at same hospital who presented symptoms of highly toxic E coli strain.
WATTAgNet3d
Enterococcus coinfection makes E. coli more deadly in poultry
The avian specific form of E. coli can lead to an infection called colibacillosis that can cause septicemia, organ failure and death.
Central Coast residents told to boil water after testing detected bacteria
An alert issued by Central Coast Council said samples from the drinking water supply contained E. coli bacteria.
Science Daily5d
Novel bacteria parasitizing archaea
Researchers have succeeded in cultivating an ultra-small bacterial strain parasitizing archaea and classified it as new species and genus of Minisyncoccus archaeiphilus. AIST researchers ...
Scientists isolate ultrasmall bacteria that parasitize methanogenic archaea
AIST researchers, in collaboration with JAMSTEC, Hokkaido University and Tohoku University, have succeeded in cultivating an ...