These may involve combining more than one guide per cell 9 or bringing orthologous CRISPR systems together 10,11 to allow for both gene activation and knockout in the same cell.

A CRISPR-based loss-of-function screen has identified host genes that are needed for SARS-CoV-2 to infect human lung cells, pointing to potential novel treatment targets for COVID-19.

Using a genomewide CRISPR screen, the Vanderbilt team discovered that deleting a protein made by the gene TRAF3 causes cells to proliferate without stopping, even after they reach a certain ...

Using a genome-wide CRISPR screen, scientists at Salk found that Foxp3, a “peacekeeping” gene in immune cells, has its expression regulated by Brd9, a subunit of the ncBAF complex.

CRISPR Therapeutics AG CRSP announced that its wholly-owned allogeneic CAR-T cell therapy, CTX110, targeting CD19+ B-cell malignancies, has been granted Regenerative Medicine Advanced Therapy ...

Discover how CRISPR gene editing is creating personalized cancer therapies, enhancing immunotherapy, and offering new hope ...

Using CRISPR-Cas9, scientists can make precise changes to the genome during brain development, and then closely study how those changes affect individual cells using single-cell transcriptomic ...

CTX110 (CRISPR Therapeutics) is an allogeneic, CD19-targeted, CRISPR/Cas9 gene-edited CAR T-cell therapy designed to treat CD19-positive B-cell malignancies.

News Release 18-Sep-2018 CRISPR screen reveals new targets in more than half of all squamous cell carcinomas Peer-Reviewed Publication University of Colorado Anschutz Medical Campus ...