A defining duo of the first Donald Trump administration is back.

WASHINGTON—Two centrist Republican senators said they opposed the nomination of President Trump’s defense-secretary pick, Pete Hegseth, injecting new drama into what was expected to be a nail-biter of a vote Friday.

Pete Hegseth has lost the support of two GOP senators ahead of a final confirmation vote. Trump's pick to lead the Department of Defense still seems to have a majority of senators in his corner. However,

Alaska Senator Lisa Murkowski announced that she would not back President Donald Trump’s controversial Pentagon nominee, and Maine Senator Susan Collins has also voiced her disapproval.

WASHINGTON — U.S. Senate Republicans on Thursday advanced the nomination of veteran and onetime Fox News host Pete Hegseth to lead the nation’s military, despite numerous allegations of alcohol abuse and sexual misconduct, and his history of disparaging women in the armed forces.

Sen. Lisa Murkowski announced Thursday that she would vote against confirming Pete Hegseth to lead the Pentagon, becoming the first Republican to oppose one of President Donald Trump’s Cabinet picks. Maine GOP Sen. Susan Collins also voted against Hegseth.

Two Republicans, Sen. Lisa Murkowski of Alaska and Sen. Susan Collins of Maine, broke ranks and voted against nominating Hegseth.

Both Republican Sens. Susan Collins and Lisa Murkowski voted "no" in a procedural vote on Hegseth's confirmation Thursday.

Senators voted 51-49 to advance Hegseth's defense secretary bid, which has been mired in a series of controversies. Two Republicans are opposed to Hegseth.

The Alaska Republican plans to vote against the confirmation of Pete Hegseth to lead the Department of Defense.

Pete Hegseth is on track to be secretary of defense, despite Murkowski's opposition. He has denied multiple allegations of alcohol abuse, financial mismanagement and violence against women.

Sen. Lisa Murkowski won't support Hegseth to lead Pentagon, becoming the first Republican to oppose a Trump Cabinet pick.