U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature, 2010; DOI: 10.1038/nature09479 ...

Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging, 2022; DOI: 10.1038/s43587-022-00290-0 ...

However, little is known about their targets. Here we show that SRPK1 is predominantly associated with U1 small nuclear ribonucleoprotein (snRNP), whereas SRPK2 associates with the U4/U6-U5 tri-snRNP.

Early spliceosome assembly requires phosphorylation of U1-70K, a constituent of the U1 small nuclear ribonucleoprotein (snRNP), but it is unclear which sites are phosphorylated, and by what enzyme, ...

The work was funded by the German Research Foundation. Study: Mangilet et al. The Arabidopsis U1 snRNP regulates mRNA 3’-end processing. Nature Plants (2024). doi: 10.1038/s41477-024-01796-8 ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

Images of the model plant Arabidopsis thaliana. In the plant on the right, the activity of the protein-RNA complex "U1 snRNP" was artificially reduced. The plants are 21 days old. Disclaimer: AAAS ...

U1 Adaptors are a recently reported novel approach for targeted reduction of mRNA transcripts. A U1 adaptor oligonucleotide comprising of a target-complimentary hybridization domain and a U1 ...

Ceptur’s use of synthetic oligonucleotides that engage U1 snRNP offers the ability to co-opt this master regulator of the transcriptome to regulate mRNA in a highly targeted fashion.

U1 contributes to the spliceosome complex that enacts the essential first steps of intron excision. To characterize insoluble U1 snRNP in Alzheimer’s, the researchers located the complex in 30 AD ...

Ceptur’s use of synthetic oligonucleotides that engage U1 snRNP offers the ability to co-opt this master regulator of the transcriptome to regulate mRNA in a highly targeted fashion.