Human bone develops in one of two ways: direct formation of bone cells from mesenchymal progenitor cells, or through endochondral ossification, in which cartilage forms first and then coverts to bone.

Liu Yang, Kwok Yeung Tsang, Hoi Ching Tang, Danny Chan, Kathryn S. E. Cheah, Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation, Proceedings of the National ...

These cells were found to contribute significantly to heterotopic cartilage formation during the endochondral ossification phase, with around one-fifth of cartilage cells derived from Tppp3 ...

On January 2, 2025, a study (DOI: 10.1038/s41413-024-00391-z) published in Bone Research unveiled the pivotal role of Discoidin Domain Receptor 2 (DDR2) in BMP signaling. Conducted by a team at ...