Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis.

Notably, TFEB and TFE3 are present across the animal kingdom, indicating that STING-induced autophagy-lysosome pathway is more evolutionarily ancient than its inflammation function, which is only ...

Researchers at Zhejiang University found that acute stress increases natural repair mechanisms in the brain, while chronic ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...