Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

In this study, the researchers revealed that autophagy pathway in astrocytes (non-neuronal cells in the brain) removes amyloid-beta (Aβ) oligomers, the toxic proteins found in the brains of AD ...

Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis.

"In Purkinje cells, ATG5 actively regulates metabolic pathways to prevent cell death." Professor Dr. Kononenko added, "These ...

A Dundee academic has been awarded a prestigious national prize for his work on neurodegenerative diseases, including ...

Unlike animals, plants do not possess an adaptive immune system with antibodies or T cells to fight viral infections. Instead ...

Researchers have found cold-water acclimation affects cellular function, upregulating protective mechanisms that could ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

The ssRNA viruses have been known to exploit endosomal vesicular trafficking's pathways associated with autophagy signaling. The non-structural proteins are the key players to interfere with these ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...