One of the main factors determining therapeutic antibodies’ half-life is the interaction between the antibody’s Fc region and ...

In our immune system, antibodies recognize viruses, bacteria and even cancer cells through their Fab arms, initiating recruitment of leucocytes for the destruction of these invaders. The recruitment ...

Each of these four IgG subclasses is structurally similar and comprised of a hinge region, Fab region (variable) and Fc region (constant). Figure 2. Four IgG subclasses. Image Credit: ACROBiosystems ...

Understanding these glycosylation patterns is just as important as analyzing other tools like labeled peptides, which are ...

Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ receptors with ...

John C. Brown, Marian E. Koshland, Activation of Antibody Fc Function by Antigen-Induced Conformational Changes, Proceedings of the National Academy of Sciences of the United States of America, Vol.

Zymeworks Announces Antibody Fc Engineering Collaboration and License Agreement with GSK December 03, 2015 05:00 AM Eastern Standard Time ...

Note that intact mAb, Fab/Fc, and Lc/Hc can all be separated using exactly the same chromatographic method. Figure 1.

Methods: MGAH22 was compared to RES120, an identical mAb except for a wild type Fc domain. Antibody-dependent cell cytotoxicity (ADCC) assays were performed with HER2-expressing cancer cells and human ...