Understanding these glycosylation patterns is just as important as analyzing other tools like labeled peptides, which are ...

One of the main factors determining therapeutic antibodies’ half-life is the interaction between the antibody’s Fc region and ...

FcResolv NOG models eliminate the false negatives that occur when an antibody-based therapeutic’s Fc domain interacts with murine FcγRs as well as the false positives that result when FcγRs ...

Each of these four IgG subclasses is structurally similar and comprised of a hinge region, Fab region (variable) and Fc region (constant). Figure 2. Four IgG subclasses. Image Credit: ACROBiosystems ...

In our immune system, antibodies recognize viruses, bacteria and even cancer cells through their Fab arms, initiating recruitment of leucocytes for the destruction of these invaders. The recruitment ...

Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcγ receptors with ...

John C. Brown, Marian E. Koshland, Activation of Antibody Fc Function by Antigen-Induced Conformational Changes, Proceedings of the National Academy of Sciences of the United States of America, Vol.