Here we demonstrate that expression of the splicing factor CELF2 (CUGBP, Elav-like family member 2) is regulated in response to T-cell signaling through combined increases in transcription and mRNA ...

The specific mechanisms by which splicing promotes gene expression have also been extensively investigated, revealing that splicing affects several steps, including transcription, total mRNA levels, ...

Pre-mRNA splicing is a fundamental step in mRNA maturation and its discovery in 1977 revolutionized our understanding of gene expression. This collection includes reviews and research articles ...

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing -- a critical step in the earliest stage of protein production.

Splicing of a pre-mRNA molecule occurs in several steps that are catalyzed by small nuclear ribonucleoproteins (snRNPs). After the U1 snRNP binds to the 5′ splice site, the 5′ end of the ...

1 Introduction Alternative pre-mRNA splicing is a critical molecular mechanism underlying the generation of diverse proteins and plays a pivotal role in various biological processes, such as ...

Background: GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in ...

Due to the low number of precursor RNA captured in our dataset (Appendix Fig S4B), we decided to adjust our model to increase the robustness of the transcription and degradation rates at the cost of ...

GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene ...