New therapeutic possibilities for various diseases are made possible via mRNA. The adaptability of in vitro transcribed (IVT) mRNA is largely due to its simpler cell-free manufacture, cell cycle ...

In vitro-transcribed (IVT) mRNA encoding therapeutic proteins ... not only thwarted the immune reaction to mRNA, but also improved its translational efficiency, opening the door for future ...

As the first step in many workflows, in vitro transcription (IVT) has quickly emerged as an essential part of successful mRNA therapeutic manufacturing processes, optimizing and accelerating ...

The importance of in vitro transcription as a component of the mRNA therapeutic manufacturing workflow has grown significantly in recent years. The in-process raw materials for synthetic mRNA ...

A team of researchers led by Dr. KIM V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of ...

Caption Genome-wide CRISPR knockout screens to identify cellular regulators of LNP-based mRNA vaccines. mRNAs encoding Green Fluorescent Protein (GFP) were in vitro transcribed (IVT) and delivered ...