As the first step in many workflows, in vitro transcription (IVT) has quickly emerged as an essential part of successful mRNA therapeutic manufacturing processes, optimizing and accelerating ...

New therapeutic possibilities for various diseases are made possible via mRNA. The adaptability of in vitro transcribed (IVT) mRNA is largely due to its simpler cell-free manufacture, cell cycle ...

In vitro-transcribed (IVT) mRNA encoding therapeutic proteins ... not only thwarted the immune reaction to mRNA, but also improved its translational efficiency, opening the door for future ...

Creating these mRNA-based medicines of the future requires ... and other undesirable by-products of IVT reactions (Fig. 1). Improvements in these key IVT performance indicators translate into ...

The importance of in vitro transcription as a component of the mRNA therapeutic manufacturing workflow has grown significantly in recent years. The in-process raw materials for synthetic mRNA ...

and reduces IVT cost. In a press release issued at the time, Zieler said, “We are excited to work with ExPLoRNA to bring industry leading mRNA cap analogs to the market and pairing them with Primrose ...