Fibroblasts, which are found in connective tissue such as ligaments and tendons, long have been viewed by scientists as crucial but dull, quietly performing their essential function of providing the ...

During fibrosis, fibroblasts — connective tissue cells that synthesize the extracellular matrix — “become somehow dysregulated, either by injury or by mutation,” he added. “These fibroblast cells ...

The primary function of fibroblasts is the maintenance of structural integrity within the connective tissue. Fibroblasts secrete the extracellular matrix precursors required for the formation of ...

"We have investigated the pattern of gene expression in the connective tissue cells – known as fibroblasts – with a sensitive technique that enables the analysis of one cell at a time.

The insights relate to the mechanical factors that play a critical role in the differentiation and function of fibroblasts and connective tissue cells that play a role in wound healing and scar ...

identified the two cell types that help cancer cells to metastasize after examining 768 connective tissue cells in a mouse with breast cancer. Advertisement Vascular fibroblasts are the cells ...

More information: Marta Torregrossa et al, Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans, Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. Together, this extracellular matrix and collagen form the structural framework of tissues in ...