Insights into the function of DNA Topoisomerase VI (Topo VI) may provide a springboard for drug discovery and crop protection ...

The FDA has approved Blujepa (gepotidacin) for the treatment of female patients 12 years of age and older weighing at least 40kg with uncomplicated UTI.

The FDA has approved the drug for use in women and girls over the age of 12 who suffer from uncomplicated urinary tract ...

Management of chromosome shape and topology in bacteria falls to three groups of proteins: the DNA topoisomerases, the structural maintenance of chromosome proteins (SMC), and the small double-strand ...

They demonstrated that this complex cleaves DNA and covalently attaches to the ... distinct from its ancestral enzyme, ...

Scientists at Charles University and Mayo Foundation for Medical Education and Research (MFMER) have synthesized DNA topoisomerase II β inhibitors reported to be useful for the treatment of ...

The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV (both Type II topoisomerases), which are required for bacterial ...