In the three years since Christina Applegate was diagnosed with multiple sclerosis, the actress’ medical condition has steadily progressed. During a recent episode of her podcast MeSsy — co-hosted with Jamie-Lynn Sigler, who also received a MS diagnosis — she detailed the chronic pain she faces and how it impacts her daily life.

I lay in bed screaming'Christina Applegate has shared the grueling effects of her battle with Multiple Sclerosis. The “Dead To Me”

Christina Applegate will not suppress how difficult her battle with multiple sclerosis is. During the Monday, November 5, episode of her "MeSsy" podcast with Jamie-Lynn Sigler, who also has the medical condition,

She detailed the effect the autoimmune disease, “I can’t even pick up my phone sometimes…or get my remote…sometimes I can’t even hold them. I can’t open bottles now.”

Speaking with her co-host Jamie-Lynn Sigler, who also has MS, on the latest episode of their MeSsy podcast, Applegate said, “I lay in bed screaming, like, the sharp pains, the ache, the squeezing.”

Christina Applegate has shared the horrific experiences she goes through living with multiple sclerosis (MS). The star was diagnosed with the condition following advice from fellow actor Selma Blair, who she confided in about strange symptoms she was experiencing.

"I can't even pick up my phone sometimes because now it's traveled into my hands, so I'll, like, try to go get my phone or get my remote to turn on the TV or sometimes, I can't even hold them. I can't open bottles now.