This makes CD45 antibodies a very useful tool for live imaging, and it sets the stage for the development of other antibody-based labels that can be used to target specific immune cell subsets.

Hot Papers H. Charbonneau, N.K. Tonks, K.A. Walsh, E.H. Fischer, "The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase," PNAS, 85, 7182-86, October 1988. Harry ...

The research team first looked at the canonical leukocyte marker CD45 in serum samples. Serum samples from mild cases had decreased the number of CD45+ extracellular vesicles.

In the study, published today in Science Translational Medicine, the researchers used engineered CAR T cells to target CD45—a surface marker found on nearly all blood cells, including nearly all ...