We identified USP17 as a novel deubiquitinating enzyme regulating c-Myc levels to control cell proliferation. Overexpression of USP17 stabilized the c-Myc protein by promoting its deubiquitination ...

The targeted knockout of the c-myc gene from rat fibroblasts leads to a stable defect in cell proliferation. We used complex cDNA libraries expressed from retroviral vectors and an efficient ...

Researchers have developed a peptide that targets a protein implicated in 75% of human cancers and found that it slowed the proliferation of cancer cells in the lab. It’s the first step towards ...

Due to radiation damage and the increase of c-MYC in progenitor cells, inflammation in the intestine increases and mitogenic protein levels are reduced; however, by removing or inhibiting c-MYC ...

c-MYC is a well-validated oncogene with broad anti-cancer potential, as c-MYC expression is dysregulated in more than 70% of cancers and a key regulator in nearly every aspect of the oncogenic ...

The MYC super-enhancer region on chromosome 8q24 contains cancer risk variants such as the G-allele of SNP rs6983267, which is present in over half of people with European ancestry and a majority ...

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...

More information: Andrew Kent et al, A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis, Nature Immunology (2025). DOI: 10.1038/s41590-024-02028-z Provided by Cornell University ...

- In a healthy tissue, cell growth and proliferation are tightly controlled processes. During development of cancer, cells escape these control mechanisms and grow uncontrollably, explains senior ...