Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Science Immunology, 2022; 7 (73) DOI: 10.1126/sciimmunol.abm3723 ...

News Release 8-Jul-2022 Scientists analyze structure of antibodies that could be key to more effective cancer treatments Peer-Reviewed Publication University of Southampton ...

The company said it plans to develop its new Chai‑2 platform to design, from square one, completely new antibodies for ...

Antibodies usually have a Y-shaped structure, and these hypervariable regions are located in the tips of the Y, where they detect and bind to foreign proteins, also known as antigens.

However, the reason why it is more active had not been determined. What was known, however, is that the structure between the antibody arms, the so-called hinges, changes over time.

Weitzner et al. describe a computational protocol that uses RosettaAntibody to predict antibody structures from sequence data. SnugDock is then used for docking of these structures to protein ...

The flexibility of the structure between the arms of an antibody—the so-called “hinge”—influences the strength of its immune response. This finding could lead to the design of antibody ...

Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. mBio, 2018; 9 (5) DOI: 10.1128/mBio.01674-18 ...

Coronavirus: Blood Types and Their Antibodies Could Be Vital to Understanding How the Body Fights COVID-19 Published Mar 19, 2020 at 6:29 AM EDT By Glenda Mary Davison Newsweek Is A Trust Project ...

Scientists at Fred Hutchinson Cancer Research Center in Seattle have shown that a potent antibody from a COVID-19 survivor interferes with a key feature on the surface of the coronavirus’s distinctive ...