If your mouse uses an external receiver that plugs into a USB port, try a different port. You can also try using your wireless mouse on another computer to see if the problem follows the mouse.

If your keyboard or mouse is not working in BIOS, try other USB ports, If this does not work, use these solutions to fix the issue.

My wife's computer has been having a very, very similar problem!<P>Every so often, the keyboard and mouse will stop responding. Zilch, nada, nothin'.