Tight control of separase activity is essential for prolonged meiotic arrest of mammalian oocytes. Here, removal of securin and cyclin B1-Cdk1 dual inhibition of separase in mouse oocytes leads to ...

Analyses of zebrafish meioc mutants revealed that spermatogonial stem cells with low rRNA transcription caused by nucleolar Piwil1 require Meioc to keep Piwil1 in cytoplasm for the upregulation of ...

The enzyme SPO11 has a crucial role in meiosis, the process that forms sperm and egg cells. The activity of purified SPO11 has now been reconstituted in a cell-free system — enabling the enzyme ...