However, ACE inhibitors and ARBs exert opposite effects on angiotensin II, and thus could lead to differential expression and activity of ACE2. Experimental animal data suggest that RAAS inhibition ...

Low plasma renin activity due to volume expansion is a feature common to these disorders; the disorders can be characterized further into syndromes of increased or decreased aldosterone synthesis.

Smith, J. P., et al. (2024) Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State. Hypertension. doi.org/10.1161/hypertensionaha.124.22886.