This connection is mediated by multi-protein complexes called focal adhesions. A critical component of focal adhesions is integrin, a transmembrane-receptor protein. “The mechanism for integrin ...

Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM). Light: Science & Applications, 2018; 7 (1) DOI: 10.1038/s41377-018-0001-5 ...

Immunofluorescence image showing S100A11 (green) localization to focal adhesions and actin stress fibers in a HeLa cell. Microtubules are labeled in red. Researchers at Kanazawa University report ...

Examining focal adhesions is one of the key elements to understanding how a cell proliferates, differentiates, and migrates--which can help in the treatment of diseases like cancer.

A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details of the activation of the Focal Adhesion Kinase (FAK) on lipid membranes. Lietha started this ...

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades. However ...

We are interested in the molecular mechanisms connecting the focal adhesions to transcriptional regulation of pluripotency," says Academy Professor Johanna Ivaska from the Turku Bioscience Centre.

'Focal Adhesion Kinase (FAK) Inhibitor - Pipeline Insight, 2018' reportoffers comprehensive insights of the pipeline (under development) therapeutics scenario and growth prospects across Focal ...

The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal ...

Focal Adhesion Kinase as a Therapeutic Target for Meningiomas With Somatic Neurofibromatosis Type 2 Mutations The following represents disclosure information provided by the author of this manuscript.