The mechanosensitivity of integrin-based adhesions (focal adhesions) is attributable to the complexity and modularity of the adhesion complexes, and their different functional modules ...

Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a role in several signaling pathways. Paxillin contains a number of motifs that mediate protein–protein ...

Focal adhesions and hemidesmosomes as integrin-dependent junctions for cell-matrix adhesion There are two types of integrin-dependent junctions where cell-matrix adhesion occurs. The first are ...

Focal adhesion (FA) proteins may be critical elements in the production of dystrophic neurites in Alzheimer's disease, according to research presented in the January 15 Journal of Neuroscience. Recent ...

Even more fascinating is the intricate relationship between lysosomal exocytosis and focal adhesions, structures critical for cell anchoring and communication. By decoding how focal adhesions ...

A group of researchers led by Dr. He Kangmin from the Institute of Genetics and Developmental Biology and Dr. Fang Xiaohong from Hangzhou Institute of Medicine, has identified focal adhesions as ...

Cell-extracellular matrix adhesions are formed at two types of integrin-dependent junction: focal adhesions and hemidesmosomes. Focal adhesions occur at the attachment site of the cell ...

This screen shot of a migrating human skin cell shows focal adhesion sites with which cells attach to the extracellular matrix in purple, and receptors that link microtubules to focal adhesions in two ...

Verastem will present data on the targeted inhibition of Focal Adhesion Kinase (FAK) in mesothelioma. Approximately 50% of patients with mesothelioma harbor a specific genetic lesion in the gene ...