This connection is mediated by multi-protein complexes called focal adhesions. A critical component of focal adhesions is integrin, a transmembrane-receptor protein. “The mechanism for integrin ...

Focal Adhesion Kinase as a Therapeutic Target for Meningiomas With Somatic Neurofibromatosis Type 2 Mutations The following represents disclosure information provided by the author of this manuscript.

Amplia Therapeutics Ltd. is raising AU$27.5 million (US$18.12 million) to advance lead compound narmafotinib (AMP-945), a focal adhesion kinase (FAK) inhibitor, into new indications beyond pancreatic ...

A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details of the activation of the Focal Adhesion Kinase (FAK) on lipid membranes. Lietha started this ...

Immunofluorescence image showing S100A11 (green) localization to focal adhesions and actin stress fibers in a HeLa cell. Microtubules are labeled in red. Researchers at Kanazawa University report ...

The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal ...