The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and damaged material, proxy inflammation to attract additional phagocytes, and ...

That breakdown can activate the complement system. A series of proteins in the system, numbered C1 to C9, get activated sequentially and undergo splitting to form fragments, such C3a and C3b or ...

Acute chest syndrome associated with sickle cell is driven by the abnormal activation of the complement cascade, per a study.

Granzyme K activates the entire complement cascade. Nature, 2025; DOI: 10.1038/s41586-025-08713-9 ...

The complement system comprises 30 proteins that are involved in the classical, alternate, and lectin pathways, all of which converge in C3 cleavage, a major complement component.

That residual virus could keep the complement system active. Or it’s possible that lingering tissue damage keeps the system engaged. Or maybe it’s something else entirely.

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity. This significantly ...

Repeated blood samples turned up important differences in their blood: A group of proteins indicated that a part of the body’s immune system called the complement system remained activated long ...