That breakdown can activate the complement system. A series of proteins in the system, numbered C1 to C9, get activated sequentially and undergo splitting to form fragments, such C3a and C3b or ...

New research uncovers an immune pathway driving acute chest syndrome in sickle cell disease; blocking it with approved drugs ...

The complement system also plays a role in inflammation that can lead to rejection of organ transplants. Studies in animal models of organ transplants helped to show how targeting C3 could help.

The complement system comprises a group of proteins in the immune system that recognize and neutralize bacteria and viruses, including nanoparticles, which are foreign to the body. This immune ...

Acute chest syndrome associated with sickle cell is driven by the abnormal activation of the complement cascade, per a study.

Acute chest syndrome (ACS), a life-threatening complication of sickle cell disease (SCD), may be driven by overactivation of ...

A new study has developed an innovative approach to combat antibiotic-resistant bacteria by tagging them with a chimeric agent that activates the immune system towards them. This approach not only ...

The complement system comprises 30 proteins that are involved in the classical, alternate, and lectin pathways, all of which converge in C3 cleavage, a major complement component.

Researchers from Cytovia Therapeutics Inc. have presented preclinical data for the novel natural killer (NK) cell engager antibody CYT-338, which was designed using the proprietary FLEX-NKTM platform.

That residual virus could keep the complement system active. Or it’s possible that lingering tissue damage keeps the system engaged. Or maybe it’s something else entirely.

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity. This significantly ...