The vitamin D obtained from these sources is biologically inert and must undergo hydroxylation within the body in order to offer a functional use. Several organ systems benefit from the presence ...

failure These conditions may lead to a vitamin D deficiency because they can affect the liver enzyme 25-hydroxylation, a protein that converts vitamin D into its active form in the body after it ...

In the body, vitamin D is initially inert; successive hydroxylation reactions in the liver and kidneys produce the biologically active form. In humans, most circulating vitamin D is made in the skin ...

That means that to use vitamin D, your body needs to convert it using your liver and kidneys. This process, known as hydroxylation, is what allows your body to use vitamin D for various vital ...

For Vitamin D to be activated in the body, it needs to go through two hydroxylation processes—first in the liver and then in the kidneys. Here is where magnesium plays a crucial role ...

it can also enhance vitamin D hydroxylation and breakdown by inducing the expression of CYP3A4. This explains how SXR activators can cause osteomalacia. The study establishes SXR as a potential ...

Vitamin D responsiveness is also dependent on the relative activity of cytochrome P450 enzymes CYP27B1 and CYP24A1, because a reduction in local 1-hydroxylation or increased 24-hydroxylation ...

where a second hydroxylation occurs at the 1 position, converting it to 1,25-dihydroxy cholecalciferol, the bioactive form of vitamin D. The production of this active form is regulated by an ...