Andrew M. Collins, Yan Wang, Krishna M. Roskin, Christopher P. Marquis, Katherine J. L. Jackson, The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred ...

Impact of immunoglobulin heavy chain variable region mutational status on the outcome of patients with chronic lymphocytic leukemia harboring isolated 13q deletion. Authors: Gelenis C. Domingo, Samir ...

Purpose Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease for which natural history can be predicted based on the presence or absence of immunoglobulin (Ig) variable heavy chain ...

Total RNA was extracted from the PBMCs followed by cDNA synthesis for amplifying variable heavy domain of heavy chain (VHH) gene regions. The PCR products were then ligated into the phagemid vector, ...

A potential solution to viral immune escape is using camelid Variable Heavy chain domains of a Heavy chain (VHHs) or nanobodies, which are capable of recognizing epitopes that are often ...

Maerivoet, A., et al. (2024) Enhanced stabilisation and reduced fibril forming potential of an amyloidogenic light chain using a variable heavy domain to mimic the homodimer complex. The FEBS ...

Abstract The aim of this study was to clone the gene encoding the light chain variable region (V (L)) of the murine myeloma cell line P3/NS1/1-Ag4-1 (NS-1). Total RNA was prepared from the NS-1 cell ...