To test if uridine truly plays a role in hunger and food consumption, Hanssen et al. (2023) measured uridine levels in the blood of 39 young adults before, during, and after they ate at a buffet.

Unlike pseudouridine, uridine has an N-glycosidic bond, which is cleaved into ribose-1-phosphate (sugar) and uracil during natural degradation in cells by means of the enzyme uridine phosphorylase.

It's because cancer cells are perfectly willing to switch to another fuel source – uridine (Figure 1). Figure 1. (L) Glucose, the primary fuel of the body. (R) The chemical structure of uridine ...

Free radicals produced by the reactions of OH radicals with uridine were investigated by a method combining ESR, spin-trapping, and liquid chromatography. A $ {\rm N}_ {2} {\rm O}\text {-saturated}$ ...

Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature, 2023; DOI: 10.1038/s41586-023-06073-w ...

Background: 5-fluorouracil (5-FU) is widely used to treat solid tumors and is often administered via infusion pump at or near its maximum tolerated dose. The common use of infusion pumps loaded with 5 ...

István Szanyi, Gábor Ráth, Péter Móricz, Krisztina Somogyvári, Péter Révész, Imre Gerlinger, Zsuzsanna Orsós, István Ember, István Kiss, Effects of cytochrome P450 1A1 and ...