Urea Cycle: A series of biochemical reactions in the liver that detoxify ammonia by converting it into urea, subsequently excreted via the kidneys.

Hyperammonemia can be due to genetic disorders or acquired health problems, such as liver disease or kidney failure. Around 90% of hyperammonemia cases in adults are related to cirrhosis of the liver.

“This seemingly small discovery, that some new materials can remove urea from the blood, could actually have quite a significant impact on the quality of lives for people with kidney failure,” said ...

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metabolism, 2024; DOI: 10.1016/j.cmet.2024.07.007 ...