The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

Selective protein degradation by the ubiquitin–proteasome pathway is a fundamental regulatory strategy that fulfils essential roles in various cellular processes. In recognition of the central ...

The intricate ubiquitin-proteasome system (UPS ... ferroptotic, and pyroptotic pathways. By selectively modulating proteins involved in these pathways, USPs contribute to either promoting or ...

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions ...

Recently, the research teams led by Professors Yu Tao and Feng Yugong from The Affiliated Hospital of Qingdao University ...

Published in Genes & Diseases, this article explores the intricate mechanisms through which the ubiquitin (Ub) system regulates key pathways essential for CSC maintenance and survival ...

(Cited in nearly 120 publications as of February 1997) IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquitin ...