Figure 6: The N-end rule pathway. Subunit selectivity of protein degradation was yet another fundamental feature of the ubiquitin system that was first discovered in the N-end rule pathway.

In eukaryotic cells, a ubiquitin conjugation cascade pathway exists to enzymatically activate ubiquitin, which then becomes covalently attached to substrate proteins that are destined for proteolysis.

Though recent discoveries have revealed how rice plants mitigate such threats by initiating immune responses against ...

(Cited in nearly 120 publications as of February 1997) IN ON THE GROUND FLOOR: This review summarized the state of the field when many people were just starting to get interested in the ubiquitin ...

The intricate ubiquitin-proteasome system (UPS ... ferroptotic, and pyroptotic pathways. By selectively modulating proteins involved in these pathways, USPs contribute to either promoting or ...

Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...

Published in Genes & Diseases, this article explores the intricate mechanisms through which the ubiquitin (Ub) system regulates key pathways essential for CSC maintenance and survival ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

influence various cell death pathways crucial to cancer progression and treatment response. The intricate ubiquitin-proteasome system (UPS) plays a vital role in maintaining cellular homeostasis ...