An immune system defect makes affected individuals vulnerable to severe viral diseases such as influenza or COVID-19. It is ...

Recent insights reveal the potential role of interferon (IFN) signaling in the pathogenesis of OPLL, particularly the type I IFN pathway, which is known to play a role in innate immune responses ...

Moreover, type I interferon (IFN) signaling was enhanced in Treg cells from both EORA patients and aged arthritic mice, with ...

A study from St. Jude Children’s Research Hospital reveals that the protein VDAC2 acts as a “signal jammer” in tumors, ...

An immune system defect makes affected individuals vulnerable to severe viral diseases such as influenza or COVID-19. It is caused by the body's own antibodies, which inhibit important defense ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Interferons are proteins that help fight infection. Typically, BCG induces a strong Type I interferon response, which in turns leads to higher levels of IDO.

An immune system defect makes affected individuals vulnerable to severe viral diseases such as influenza or COVID-19. It is caused by the body's own antibodies, which inhibit important defense ...