Because tumor vessels are malformed, Ghosh wondered whether tumor capillary cells have lost the normal cells' ability to sense and respond to changes in matrix stiffness and distortion.

How metastatic cancer causes leaky blood vessels Direct contact between cancer and blood cells changes their normal clockwise orientation to a more metastasis-prone counterclockwise position Date ...

The researchers found that cells in the blood-vessel wall expressed high levels of transforming growth factor-β (TGF-β) and activin in the presence of a migrating tumor cell cluster. This was ...

So, knowing the importance of blood vessel formation for cancers, and understanding how they do that, has created a number of targets to various components of that pathway. A drug like bevacizumab ...

The ability to get a drug into a tumor poses a challenge for treating many types of cancer. The poorly functioning vessels developed by tumors restrict the delivery of anti-cancer therapies into the ...

Pericytes are peculiar cells that look a bit like little octopuses tightly embracing the surface of blood vessels. In tumors, they are abnormal. Their cell bodies are only loosely associated with the ...

The contribution of my research groups will be to develop a novel viral vector that can specifically target tumor vessels while sparing normal blood vessels", says Magnus Essand.

Contrary to a long-standing assumption that blood vessel cells in healthy tissues and those associated with tumors are similar, a new study unequivocally demonstrates that tumor blood vessel cells ...

Merlin-deficient mice implanted with human lung cancer showed an impressive 80.6% reduction in tumor growth after 3 weeks in comparison to regular mice.