One of these pathways, called the kynurenine pathway, is the principal pathway involved in metabolizing the amino acid tryptophan. Now, a new study by a team of scientists, led by Professor Kuniaki ...

The faster the kynurenine pathway, the faster tryptophan is degraded. Controlling the speed of the kynurenine pathway is the enzyme TDO2 -- which happened to be the most upregulated gene in ...

In mice that express a celiac disease susceptibility gene, impaired tryptophan metabolism promoted celiac disease inflammation. Lamas et al. show that a high-tryptophan diet can shift the gut ...

If we are sick or stressed, tryptophan may take a different route than the usual kynurenine pathway (also known as the tryptophan degradation pathway). When this pathway is overactive, tryptophan ...

The five-year award will run through May 2029. More than 90 percent of tryptophan (Trp), an essential amino acid that humans obtain through diet, is utilized by the kynurenine (KYN) pathway primarily ...

In recent years, dozens of studies have investigated the association between tryptophan metabolism, serotonin production, and various mental health disorders. Notably, when tryptophan breaks down ...

A recent study published in the journal Nature Microbiology examines tryptophan metabolism in response to increased dietary fiber intake. Study: Dietary fibre directs microbial tryptophan ...

One of these pathways, called the kynurenine pathway, is the principal pathway involved in metabolizing the amino acid tryptophan. Now, a new study by a team of scientists, led by Professor Kuniaki ...