"Various lines of scientific evidence suggest that tryptophan metabolism is involved in the symptoms of major depressive disorder," notes Dr Yamamoto. For example, past studies have reported that ...

We discovered and identified 16 differential metabolites in the olfactory bulb of the CMS treatments. Metabolic pathway analysis by MetaboAnalyst 5.0 was generated according to the differential ...

Tryptophan is a precursor of serotonin, the neurotransmitter responsible for mood. The researchers determined the structure and mechanism of an enzyme in the kynurenine pathway, AMSDH.

Significant alterations in L-Tryptophan (Trp) metabolism have been identified among several chronic inflammatory pathologies, including multiple sclerosis (MS). There are three metabolic routes ...

Using genetically modified mice lacking Tph1, the researchers found that plasma and brain levels of tryptophan and its metabolites in young Tph1 mutants were significantly lower than those in ...

The tryptophan (Trp) biosynthetic pathway leads to the production of many secondary metabolites with diverse functions, and its regulation is predicted to respond to the needs for both protein ...