One of these pathways, called the kynurenine pathway, is the principal pathway involved in metabolizing the amino acid tryptophan. Now, a new study by a team of scientists, led by Professor Kuniaki ...

This pathway produces several neurotransmitter regulators and is responsible for metabolizing nearly 99 percent of the tryptophan in the body. Tryptophan is a precursor of serotonin, the ...

"A tryptophan-free diet prevents liver tumor growth by a mechanism that depends on I3P but is independent of translation ...

If we are sick or stressed, tryptophan may take a different route than the usual kynurenine pathway (also known as the tryptophan degradation pathway). When this pathway is overactive, tryptophan ...

The faster the kynurenine pathway, the faster tryptophan is degraded. Controlling the speed of the kynurenine pathway is the enzyme TDO2 -- which happened to be the most upregulated gene in ...

In recent years, dozens of studies have investigated the association between tryptophan metabolism, serotonin production, and various mental health disorders. Notably, when tryptophan breaks down ...

In mice that express a celiac disease susceptibility gene, impaired tryptophan metabolism promoted celiac disease inflammation. Lamas et al. show that a high-tryptophan diet can shift the gut ...

“The ways we think about how this could lead to therapies are: How do you keep that balance tipped so that tryptophan goes towards that anti-inflammatory pathway? How can you manipulate ...

One of these pathways, called the kynurenine pathway, is the principal pathway involved in metabolizing the amino acid tryptophan. Now, a new study by a team of scientists, led by Professor Kuniaki ...