A review exploring the mechanisms of trastuzumab resistance HER2-overexpressing metastatic breast cancer and how novel strategies that target aberrant molecular pathways could improve the response.

A new study provides important insight into the mechanisms involved in resistance to treatment of breast cancer patients with trastuzumab (Herceptin). The research identifies markers that may help ...

Valabrega, G, Montemurro, F, Aglietta, M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007;1:17-17 Google Scholar ...

Dr Rimawi summarized the current data on mechanisms of resistance to anti-HER2 therapy in breast cancer. "In breast cancer, HER2 (human epidermal growth factor receptor 2) is a perfect example of ...

However, in trastuzumab-resistant breast cancer cells, this intricate network breaks down. A key regulator in the network, GDI2, is lost, leading to disruption of the α V β 6-HER2 connection.As ...

Wang Z, et al. Trastuzumab resistance in HER2-positive breast cancer: Mechanisms, emerging biomarkers and targeting agents. Front Oncol. 2022;12:1006429. Vu T, Claret FX. Trastuzumab: Updated ...

A significant breakthrough in breast cancer research has uncovered a key mechanism driving cancer invasion and drug resistance. A University of Liverpool study reveals how two critical molecules ...

A new study provides important insight into the mechanisms involved in resistance to treatment of breast cancer patients with trastuzumab (Herceptin). The research, published by Cell Press in the ...