This application of dual-reporter assays allows for protein stability reporters to be readily multiplexed with transcriptional endpoints, enabling highly precise mode-of-action studies for ...

The released NF-kB then undergoes nuclear translocation and activation, which induces the transcriptional expression of target genes (Figure 1). Luciferase reporter assays have been used widely to ...

changes in transcriptional activity. Such effects are caused by changes in transcription factor-binding patterns at gene regulatory regions like promoters, enhancers, and silencers. Classically, the ...