Key early steps in gene expression captured in real time Capturing how RNA polymerase enzymes kick off transcription Date: May 27, 2021 Source: Colorado State University Summary: Scientists have ...

They found that within 30 minutes, a core set of transcription factors that turn on genes that prompt cells to proliferate was uniformly shut down. In other experiments, this same set of ...

Low temperatures significantly impair the growth and yield of pepper plants, a critical crop in global agriculture.

All the winding, twisting, and coiling make it essentially impossible for the transcription enzymes to read a complete sequence of base pairs (i.e., a gene).

Transcription by the RNAPII enzyme takes place in several steps, each tightly controlled through the opposing functions of cyclin-dependent kinases (CDKs), which modify the enzyme by adding ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional elongation enzymes during gene expression, findings that may inform the ...

Efficient epigenetic drug discovery and development requires high-quality tools, including recombinant proteins and enzymes (Figure 1), validated antibodies, and other epigenetic assays. Figure 1.

Backtracking refers to the retrograde movement of the RNA-dependent RNA polymerase (RdRp), which is the crucial enzyme within the SARS-CoV-2 replication-transcription complex.

The result: the enzymes that transcribe DNA can’t tell the difference between these synthetic base pairs and those found in nature. “In biology, structure determines function,” said Wang.

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network. Science Advances, 2025; 11 (9) DOI: 10.1126/sciadv.adr9660 ...

For organs to develop, grow and regenerate, cells must proliferate. But when that process goes awry, leading to uncontrolled cell growth, cancer can emerge. New CU Boulder research, published in the ...