Researchers discovered peptides that permanently block a key cancer protein once thought untreatable, using a new screening ...

We often take facts we learn — like the fact that transcription factors bind to DNA — for granted. Or maybe not. See how researchers used DNA footprinting and gel shift assays to prove this idea.

In a first, scientists have identified promising drug candidates that can permanently disable a key cancer protein once deemed untreatable—a discovery that could revolutionize cancer treatment. Using ...

Scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein ...

The team, publishing in the journal Advanced Science, used a new drug discovery screening platform technology, called the Transcription Block Survival (TBS) assay, which tests a huge number of ...

General transcription factor IIIC subunit 2 (GTF3C2) is one of the polymerase III transcription-related factors. Previous studies have revealed that ...

We are also refining and applying ultrahigh-resolution spectroscopy techniques to dissect multistep complex biochemical processes using in vitro reconstituted single-molecule assays ... Elucidates RNA ...

In a study published November 4 in Cell, researchers found that the shift from worker to queen is facilitated by the response of transcription factor Krüppel homolog 1 (Kr-h1) to hormones that are ...