Talin-1, a focal adhesion protein, regulates cell–cell adhesion, and induces cytoskeletal remodeling leading to tumor cell migration and adhesion. Destabilization of the cell membrane during malignant ...

The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein. Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 2024-03-26 DOI: ...

Wegener KL, et al. Structural basis of integrin activation by talin. Cell. 2007; 128 (1):171-82 Kim C, et al. Talin activates integrins by altering the topology of the β transmembrane domain. J Cell ...

Understanding how these universal early adhesions form the building blocks for mature focal adhesions will provide new insights into focal adhesion mediated mechanosignalling and its vital role in ...

The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal ...

Journal iScience DOI 10.1016/j.isci.2025.111745 Article Title Nuclear talin-1 provides a bridge between cell adhesion and gene expression Article Publication Date 3-Jan-2025 ...

A team of researchers at Åbo Akademi University in Finland made a surprising discovery. They found that Talin-1, a protein primarily known for its role in cell adhesion at the periphery of the ...

March 30, 2021 Through the action of paxillin, cells form focal adhesions (light green streaks) to anchor themselves in their environment. [© UNIGE] ...

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. Journal of Biological Chemistry, 2021; 297 (1): 100837 DOI: 10.1016/j.jbc.2021.100837 ...

This study, titled "Spatial organization of PI3K-PI (3,4,5)P 3 -AKT signaling by focal adhesions," was published in Molecular Cell on November 1, 2024.