“Focus has been on how cells become mechanosensitive, how cell adhesion became mechanosensitive through the recruitment of mechanosensitive proteins like talin, vinculin ... known biochemical proteins ...

which allows the intracellular domain of their β-subunit to interact with focal-adhesion proteins, such as talin and α-actinin. The detailed sequence of events following ECM binding to the ...

The research further shows that if talin is removed from cells in culture ... currently available cancer drugs that stabilize focal adhesions might represent a way to restore mechanical integrity ...