Figure 1: Structure of hGPR40 in complex with the partial agonist TAK-875. The structural features of ECL2 and high lipophilicity of TAK-875 (which shows approximately 380-fold preference for ...

Takeda Pharmaceutical Co. has successfully come up with a diabetes drug that lowered blood sugar as much as an older generic medicine with fewer side effects. In a trial of 426 patients with Type ...