Harmonizing immunophenotyping assay designs facilitates integrating findings across trials, enabling biomarker identification and validation, revealing cohort-specific features and drug mechanisms as ...

Her expertise spans from assay development to validation of cell-based assays. She has previously validated flow cytometry-based T-cell memory assays for a hepatitis B vaccine phase-IV clinical ...

Acuitas Therapeutics has announced the publication of a new study in Science Immunology, titled "An IL12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses." ...

Local immune effector cell–associated toxicity syndrome is a newly identified side effect observed in many patients receiving CD19-targeting CAR T-cell therapy for autoimmune conditions.

Current clinical techniques such as immunohistochemistry cannot distinguish between normal or diseased T cells and therapy products such as CAR-T cells and TCR-T cells. Additionally, techniques such ...

Most CAR-T cells are generated using viral vectors, a technique that has proved its worth in certain diseases but is not very suitable in the brain. ''Indeed, they persist for a very long time in ...

James Passin, BioVaxys CEO, stated "We are delighted to work with Inotiv, a leading CRO, to complete a toxicity study, further advancing Covid-T, our novel low cost and scalable skin test for T ...

A clinical trial using HPV16-E6-specific TCR-T cells demonstrated no major toxicity in 17 % of patients (two out of 12), further marking the potential of targeting viral antigens in cancer treatment.

Thymidine kinase (TK) gene mutation assay (TK assay) is a conventional in vitro genotoxicity test that detects mutations in the TK gene locus, an essential housekeeping gene expressed by all cell ...

During the oral presentation “Cell Mimics As High Precision Controls for CGT Analytics and Potency Assays” Robyn Hall, Ph.D., Cell Therapy Specialist at Slingshot Biosciences, will highlight ...