CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for ...

This research roundup discusses researchers’ attempts to find a treatment for a “brain fog” that comes with CAR T-Cell therapy and a new use of CRISPR to deliver RNA segments to cellular ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That''s where Perturb-Seq comes in-a method ...

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein ...

CRISPR was a key tool in singling out the overabundance of the IL-4 protein in dysfunctional CAR-T cells. CRISPR acts as "molecular scissors" to precisely cut and alter a person's genes.

CRISPR was a key tool in singling out the overabundance of the IL-4 protein in dysfunctional CAR-T cells. CRISPR acts as "molecular scissors" to precisely cut and alter a person's genes.

This isn’t the first time Peer’s team has used CRISPR in cancer research. Back in 2020, they were the first in the world to use CRISPR to cut genes in cancer cells in mice with cell-specific ...

"With CRISPR 2.0 editing, certain molecules on CAR-T cells could be modified so that the immune system does not reject the foreign cells. This way, larger quantities of CAR-T cells can be produced ...