With new systemic treatments now available for psoriatic disease, questions remain on the comparable efficacy and safety of these therapies.

Exposure to fine particulate matter — specifically particles 2.5 µm or less in diameter, or PM2.5 — in the air signals a higher risk for systemic autoimmune rheumatic diseases, according to data.

Study: Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Image Credit: Luca9257 / Shutterstock.com Background ...

However, no disease flares occurred, Mueller said. After 3 months, eight patients with systemic lupus erythematosus showed no sign of disease activity and dramatic improvement in symptoms.

Clinically, anti-IL-17A biologics (e.g., secukinumab) demonstrate systemic benefits yet precise, tissue-targeted delivery is essential, as IL-17A blockade can exacerbate Crohn’s disease.

Systemic mastocytosis is a rare disorder causing excessive mast cell buildup in organs. Learn about symptoms, types, causes, diagnosis, and treatments that improve life expectancy.

Hematologic diseases Pernicious anemia. In patients with pernicious anemia (PA), autoimmune destruction of parietal cells in the stomach leads to atrophy of the gastric mucosa.

Dear T.S.B.: The term "lupus" generally means systemic lupus erythematosis (SLE), which is a systemic disorder (as its name suggests). So, by definition, it affects multiple systems of the body.