The substantia nigra anatomy is made up of two parts: the pars compacta (SNpc) and the pars reticulata (SNpr). Pars compacta. The SNpc is responsible for releasing dopamine to the striatum ...

Here it was neurons that project from the striatum to a nearby part of the brain, the substantia nigra. This small, dark-colored area plays an important role in reward, addiction, and movement.

In the current study the regulatory roles of dopamine D1 and D2 receptor subfamilies in the dorsal (DSTR) and ventral striatum (VSTR) and substantia nigra (SN) were investigated on muscle tone ...

Within the striatum, neurons are arranged in a labyrinth ... sends input to the substantia nigra, which is the brain's major dopamine-producing center. It took much longer to trace the output ...

Graybiel and colleagues discovered extensive connections between neural clusters of cells in the striatum and dopamine-producing cells of the substantia nigra. The dopamine-producing cells send ...

Dopaminergic substantia nigra neurons are different from most neurons in the brain because they release transmitters not just from their axons, which project to the striatum, but also from their ...

Other exploratory outcomes included target engagement with iron by deferiprone in the substantia nigra and striatum (T2* sequence), changes in brain-structure volume (three-dimensional T1 sequence ...

For example, whereas small aggregates populate the cortex and the striatum, much larger deposits are found in the substantia nigra (Chesselet et al., 2012; Price et al., 2018). Elevated levels of ...

Nostalgia-related activity mainly happens in the hippocampus, ventral striatum, and substantia nigra/ventral tegmental area. Scientists believe these systems work together to generate nostalgia, ...

Research in several animal models had confirmed that GDNF protects both substantia nigra neurons and their axons in the striatum, and an open-label trial of the neurotrophin delivered directly into ...